Dados do Trabalho

Título

First Trimester Screening for Fetal Growth Restriction and Adverse Maternal and Perinatal Outcomes

Descrição sucinta do(s) objetivo(s)

To evaluate the association between first trimester screening or no for fetal growth restriction (FGR) and adverse maternal/perinatal outcomes.

Material(is) e método(s)

Retrospective cohort study was conducted with pregnant women who underwent first trimester screening or no for FGR. Screening for FGR was performed using maternal clinical history, mean arterial pressure, and uterine artery Doppler. Pregnant women with an estimated risk of pre-eclampsia ≥ 1:155 were considered to be at high-risk, while those with an estimated risk < 1:155 were considered low-risk.

Resultados e discussão

499 cases who did not undergo first trimester screening for FGR (Group I) and 615 cases who underwent first trimester screening for FGR were evaluated (Group II). Group II had higher risk of gestational arterial hypertension (GAH) (aPR 3.78, 95%CI 2.39-5.97, p<0.001) and preterm birth (PB) < 37 weeks (aPR 4.12, 95%CI 2.22-8.39, p<0.001), and lower risk of delivery < 37 weeks of gestation (aPR 0.19, 95%CI 0.09-0.40, p<0.001) and Apgar score at the 5th minute < 7 (aPR 0.67, 95%CI 0.20-0.22, p<0.001). Pregnant women at high-risk for FGR had a higher risk of delivery < 32 weeks (3.1% vs 0.2%, OR 16.20, 95%CI 2.20-190.90, p=0.004), delivery < 37 weeks (10.7% vs 1.4%, OR 8.41, 95%CI 3.60-22. 10, p<0.0001) and lower risk of PB < 37 weeks (1.3% vs 7.0%, OR 0.17, 95%CI 0.03-0.64, p=0.0047) than those who did not undergo first trimester screening. The use of aspirin (ASA) was associated with a greater prevalence of developing GAH (8.0% vs. 2.1%, OR 4.1, 95%CI 1.77-10.10, p=0.0014) and birth weight < 2,500 grams (14.5% vs. 7.3%, OR 2.14, 95%CI 1.25-3.71, p=0.009) compared to pregnant women who not used ASA.

Conclusões

First trimester screening for FGR was not associated with adverse maternal/perinatal outcomes. Pregnant women with high-risk for FGR showed higher risk of adverse perinatal outcomes. ASA use was not associated with adverse maternal/perinatal outcomes.

Palavras Chave

First trimester screening; Fetal growth restriction; ultrasound screening

Arquivos