Dados do Trabalho

Título

Synchronous of breast cancer and neuroendocrine tumors

Descrição sucinta do(s) objetivo(s)

Our aim is to evaluate the imaging findings and diagnosis with a biopsy of a case of invasive breast cancer with axillary metastasis associated with a neuroendocrine tumor of the pancreas and lung with a history of clear cell renal cell carcinoma

História clínica

A 66-year-old woman was evaluated at our institution with a palpable mass in her left breast, with a personal history of left kidney cancer 3 years ago. She had undergone partial nephrectomy 2 years ago and on follow-up with CT scan, a pancreatic mass was found in the tail and body along with a nodular lung image. Mammography showed a non-circumscribed asymmetry in the UOE of the left breast with an ultrasound-guided irregular solid nodule at 2 o'clock position with positive vascularization measuring 19x13mm in association with a lymph node with altered echostructure BIRADS 5. Ultrasound-guided breast and axillary biopsy was consistent with poorly differentiated invasive NST carcinoma with axillary metastasis. Tomography-guided biopsy of the lung and pancreas revealed neuroendocrine tumors of the pancreas and lung.

Discussão e diagnóstico

The discovery of a synchronous malignancy is very rare.
Invasive breast cancer is a heterogeneous disease and can be classified according to histologic type and molecular diversity. Neuroendocrine tumors (NETs) can occur in almost all organ systems, as neuroendocrine cells can spread. NETs of the pancreas and lung are of low incidence. Our findings indicate that a germline cancer panel test should be considered in certain patients with a co-occurrence of breast cancer and neuroendocrine tumors. Patients with one malignancy are more predisposed to develop a second neoplasm, so clinicians should consider this possibility when new lesions appear during follow-up.

Conclusões

Synchronous invasive breast carcinoma with neuroendocrine tumors of the pancreas and lung is a rare phenomenon. Radiologic manifestations help to identify the features for a correct diagnosis. Therefore, appropriate follow-up is essential, especially in patients with a personal history of malignancy. The role of gene panel sequencing in certain patients with a combination of breast cancer and neuroendocrine tumors should be considered and has important implications for cancer surveillance.

Palavras Chave

Neuroendocrine tumors Breast cancer Imaging findings

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